The circulation of malignant lymphoid cells in thoracic duct lymph of rats with lymphosarcoma and lymphatic leukemia.
نویسندگان
چکیده
The circulation of lymphoid cells in thoracic duct lymph of rats with lymphosarcoma (LSA) and leukemia was investi gated. Rats were inoculated with. Murphy-Sturm lymphosar coma either by the i.m. route, which yields a localized tumorsimulating LSA, or by the i.v. route, which results in lymphatic leukemia (LL). Thoracic duct fistulae were estab lished in four groups of rats, including untreated normal rats, rats inoculated with normal lymphocytes, and rats inoculated with Murphy-Sturm lymphosarcoma to produce either LSA or LL. The percentage of large lymphocytes in thoracic duct lymph of rats with LSA and LL was higher than that of either control group and was greater in leukemic rats than in those with LSA. Chromosomal studies provided direct evidence for the circulation of malignant lymphoid cells to the thoracic duct of rats with either leukemia or LSA, but this phenomenon appeared to be quantitatively more significant in rats with LL.
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ورودعنوان ژورنال:
- Cancer research
دوره 30 9 شماره
صفحات -
تاریخ انتشار 1970